Studies on Peptides. CXVI. Synthesis of the Protected Docosapeptide Corresponding to the C-Terminal Portion of Human Growth Hormone Releasing Factor (GRF, Somatocrinin)

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概要

• 論文の詳細を見る

• As a starting material for the solution synthesis of a tetratetracontapeptide amide corresponding to the entire sequence of growth hormone releasing factor derived from human pancreatic tumor, a C-terminal-protected docosapeptide amide (positions 23-44) was synthesized by successive azide condensation of three peptide fragments (positions 33-44,28-32,and 23-27). Amino acid derivatives bearing protecting groups removable by trifluoromethanesulfonic acid were employed; i.e., benzyloxycarbonyl (Z), benzyl (Bzl), and mesitylene-2-sulfonyl (Mts).

• 公益社団法人日本薬学会の論文
• 1984-02-25

著者

• 木山 晋哉

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• 藤井 信孝

  Faculty of Pharmaceutical Sciences, Kyoto University

• 矢島 治明

  Faculty of Pharmaceutical Sciences, Kyoto University

• 赤路 健一

  Faculty of Pharmaceutical Sciences

• 矢島 治明

  京都大学

• 矢島 治明

  京大・薬

• 藤井 信孝

  京大 薬

• 霜倉 正徳

  Faculty of Pharmaceutical Sciences, Kyoto University

• 矢島 治明

  Faculty Of Pharmaceutical Sciences Kyoto University

• 霜倉 正徳

  Department of Medicinal Chemistry, Kyoto Pharmaceutical University

• 赤路 健一

  Faculty Of Pharmaceutical Sciences Kyoto University

• 霜倉 正徳

  Department Of Medicinal Chemistry Kyoto Pharmaceutical University

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