Studies on Peptides. XCVI. Behavior of S-Acetamidomethylcysteine Sulfoxide under Deprotecting Conditions in Peptide Synthesis

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概要

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• The sulfoxide of Boc-Cys (S-acetamidomethyl)-OH was prepared by oxidation with sodium perborate. Mercuric acetate and iodine failed to cleave the S-protecting group from the sulfoxide. Hydrogen fluoride and methanesulfonic acid partially converted the sulfoxide to S-p-methoxyphenylcysteine in the presence of anisole. A reducing reagent, thiophenol, converted the sulfoxide to acetamidomethyl phenyl sulfide and N^α-Boc-S-(phenylthio) cysteine.

• 公益社団法人日本薬学会の論文
• 1980-06-25

著者

• 藤井 信孝

  Faculty of Pharmaceutical Sciences, Kyoto University

• 矢島 治明

  Faculty of Pharmaceutical Sciences, Kyoto University

• 入江 寛

  長崎大薬

• 船越 奨

  Faculty of Pharmaceutical Sciences

• 赤路 健一

  Faculty of Pharmaceutical Sciences

• 入江 寛

  長崎大学薬学部

• 入江 寛

  Faculty Of Pharmaceutical Sciences Kyoto University

• 矢島 治明

  Faculty Of Pharmaceutical Sciences Kyoto University

• 赤路 健一

  Faculty Of Pharmaceutical Sciences Kyoto University

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