Syntheses and Biological Activities of Selenium Analogs of α-Rat Atrial Natriuretic Peptide

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概要

• 論文の詳細を見る

• α-Rat atrial natriuretic peptide (7-28) (rANP (7-28)) and a series of its analogs in which half cystine residue(s) were substituted with half selenocystine residue(s) were synthesized by using the Fmoc-based solid-phase method followed by cyclization by means of dimethylsulfoxide (DMSO)-trifluoroacetic acid (TFA) oxidation. These analogs possess comparable activities in both receptor binding and cGMP accumulation in rat vascular smooth muscle cells to those of rAMP (7-28).

• 公益社団法人日本薬学会の論文
• 1993-09-15

著者

• 大高 章

  Faculty of Pharmaceutical Sciences, Kyoto University

• 藤井 信孝

  Faculty of Pharmaceutical Sciences, Kyoto University

• 小出 隆規

  Faculty of Pharmaceutical Sciences, Kyoto University

• 北島 安雄

  Suntory Institute for Biomedical Research

• 古谷 真優美

  Suntory Institute for Biomedical Research

• 大高 章

  徳島大学大学院ヘルスバイオサイエンス研究部

• 大高 章

  京都大学 薬

• 藤井 信孝

  京都大学大学院薬学研究科 医薬創成情報科学専攻

• 大高 章

  京大 大学院薬学研究科

• 伊藤 ひろみ

  Faculty of Pharmaceutical Sciences, Kyoto University

• 伊藤 ひろみ

  Faculty Of Pharmaceutical Sciences Kyoto University

• 小出 隆規

  Faculty Of Pharmaceutical Sciences Kyoto University

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