Investigation of the Dimethylsulfoxide-Trifluoroacetic Acid Oxidation System for the Synthesis of Cystine-Containing Peptides
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概要
- 論文の詳細を見る
Disulfide bonds of peptides were effectively established between S-protected cysteine residues as well as free cysteine residues by the action of dimethylsulfoxide in trifluoroacetic acid. Oxytocin and α-human calcitonin gene-related peptide were synthesized using this oxidation system. The feasibility of this method for the formation of two disulfide bridges of apamin was also examined.
- 公益社団法人日本薬学会の論文
- 1993-06-15
著者
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大高 章
Faculty of Pharmaceutical Sciences, Kyoto University
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藤井 信孝
Faculty of Pharmaceutical Sciences, Kyoto University
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小出 隆規
Faculty of Pharmaceutical Sciences, Kyoto University
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大高 章
徳島大学大学院ヘルスバイオサイエンス研究部
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大高 章
京都大学 薬
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藤井 信孝
京都大学大学院薬学研究科 医薬創成情報科学専攻
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大高 章
京大 大学院薬学研究科
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小出 隆規
Faculty Of Pharmaceutical Sciences Kyoto University
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