Studies on Peptides. CXVIII. Synthesis of a Hybrid Growth Hormone Releasing Factor (GRF)-PHI Heptacosapeptide Amide

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概要

• 論文の詳細を見る

• A hybrid heptacosapeptide amide, consisting of growth hormone releasing factor (GRF) tetradecapeptide (1-14) and PHI tridecapeptide (15-27), was synthesized by a fragment condensation procedure, followed by deprotection with 1 M trifluoromethanesulfonic acid-thioanisole in trifluoroacetic acid. The synthetic peptide exhibited in vivo GRF activity (ca. 1/10 of that of GRF-44-NH_2), but lacked the blood pressure-decreasing activity of the parent PHI.

• 公益社団法人日本薬学会の論文
• 1984-02-25

著者

• 藤井 信孝

  Faculty of Pharmaceutical Sciences, Kyoto University

• 李 惟

  Department Of Molecular Biology Jilin University

• 李 惟

  Faculty of Pharmaceutical Science, Kyoto University

• 矢島 治明

  京都大学

• 矢島 治明

  京大・薬

• 藤井 信孝

  京大 薬

• 霜倉 正徳

  Faculty of Pharmaceutical Sciences, Kyoto University

• 矢島 治明

  Faculty Of Pharmaceutical Sciences Kyoto University

• 霜倉 正徳

  Department of Medicinal Chemistry, Kyoto Pharmaceutical University

• 霜倉 正徳

  Department Of Medicinal Chemistry Kyoto Pharmaceutical University

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