Studies on Peptides. CXL. : Synthesis of Human Gastrin-Releasing Polypeptide (hGRP)

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概要

• 論文の詳細を見る

• Human gastrin-releasing polypeptide (hGRP), which consists of 27 amino acid residues with a C-terminal amide, was synthesized by a conventional solution method, by assembling six peptide fragments followed by deprotection with 1M trifluoromethanesulfonic acid-thioanisole in trifluoroacetic acid. Met(O) employed was reduced by treatment with phenylthiotrimethylsilane in the presence of trimethylsilyl trifluoromethanesulfonate before deprotection. The synthetic peptide was as active as synthetic porcine GRP, in terms of immunoreactive gastrin release in rats.

• 社団法人日本薬学会の論文
• 1986-06-25

著者

• 矢島 治明

  Faculty of Pharmaceutical Sciences, Kyoto University

• 水田 和彦

  First Department Of Internal Medicine Faculty Of Medicine:kyoto University

• 高木 敦司

  First Department Of Internal Medicine Faculty Of Medicine Kyoto University

• 赤路 健一

  Faculty of Pharmaceutical Sciences

• 青野 充

  First Department of Internal Medicine, Faculty of Medicine

• 森賀 本幸

  First Department of Internal Medicine, Faculty of Medicine

• 久野 鈴光

  Faculty of Pharmaceutical Sciences, Kyoto University

• 久野 鈴光

  Faculty Of Pharmaceutical Sciences Kyoto University

• 池村 治

  Faculty of Pharmaceutical Sciences, Kyoto University

• 高木 敦

  First Department of Internal Medicine, University Hospital, Kyoto University

• 矢島 治明

  京都大学

• 矢島 治明

  京大・薬

• 矢島 治明

  Faculty Of Pharmaceutical Sciences Kyoto University

• 池村 治

  Faculty Of Pharmaceutical Sciences Kyoto University

• 赤路 健一

  Faculty Of Pharmaceutical Sciences Kyoto University

関連論文

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• Synthesis of Amaryllidaceae Alkaloids, (±)-Cherylline and (±)-Latifine
• Studies on Peptides. CXXXVI. : Solution-Phase Synthesis of a 37-Residue Peptide Amide Corresponding to the Entire Amino Acid Sequence of Human Calcitonin Gene-Related Peptide (hCGRP)
• Studies on Peptides. XCIV. Synthesis and Activity of Kyotorphin and Its Analogs
• Studies on Peptides. LXXIX. : By-Products derived from N^α-Protected Tryptophan by Acids
• Studies on Peptides. LXXVIII. Synthesis of the Nonacosapeptide corresponding to the Entire Amino Acid Sequence of Avian Glucagon (Duck)
• Studies on Peptides. LXXVII. Synthesis of the Protected Heptadecapeptide corresponding to Positions 13-29 of Avian Glucagon (Duck)
• Studies on Peptides. LXXIII. Examination of the Methanesulphonic Acid Procedure for the Synthesis of Peptides containing Methionine
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• Studies on Peptides. LXIX. Selective Removal of Acid Labile α-Amino Protecting Groups with Dilute Sulfonic Acids
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• Studies on Peptides. LXII. Synthesis of the Protected Octadecapeptide corresponding to Positions 26 through 43 of Porcine Gastric Inhibitory Polypeptide (GIP)
• Studies on Peptides. XLIX. Synthesis of the Octadecapeptide corresponding to the Entire Amino Acid Sequence of Porcine β-Melanocyte-stimulating Hormone
• Studies on Peptides. CXLI. : Synthesis of a 42-Residue Peptide Corresponding to the Entire Amino Acid Sequence of Porcine GIP (Glucose-Dependent Insulinotropic Polypeptide)
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• SYNTHESIS OF A 42 RESIDUE PEPTIDE CORRESPONDING TO THE ENTIRE AMINO ACID SEQUENCE OF HUMAN GIP
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