Studies on Peptides. CXLV. : Synthesis of a 27-Residue Peptide Amide Corresponding to the Entire Amino Acid Sequence of Canine Gastrin-Releasing Polypeptide (cGRP)

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概要

• 論文の詳細を見る

• Canine gastrin-releasing polypeptide (cGRP, characterized as a bombesin-like 27-residue peptide) was synthesized by successive azide condensations of 7 peptide fragments of established purity, followed by deprotection with trifluoromethanesulfonic acid in trifluoroacetic acid. Prior to deprotection, the Met(O) residue in the protected cGRP was reduced by brief treatment with phenylthiotrimethylsilane in the presence of a catalytic amount of trimethylsilyl trifluoromethanesulfonate. The homogeneous HPLC-purified product induced a significant increase of immunoreactive gastrin level in rat plasma, like synthetic human GRP.

• 社団法人日本薬学会の論文
• 1986-11-25

著者

• 矢島 治明

  Faculty of Pharmaceutical Sciences, Kyoto University

• 別所 清

  Faculty Of Pharmaceutical Sciences Kyoto University

• 高木 敦司

  First Department Of Internal Medicine Faculty Of Medicine Kyoto University

• 赤路 健一

  Faculty of Pharmaceutical Sciences

• 青野 充

  First Department of Internal Medicine, Faculty of Medicine

• 森賀 本幸

  First Department of Internal Medicine, Faculty of Medicine

• 久野 鈴光

  Faculty of Pharmaceutical Sciences, Kyoto University

• 久野 鈴光

  Faculty Of Pharmaceutical Sciences Kyoto University

• 別所 清

  College of Liberal Arts, Kyoto University

• 矢島 治明

  京都大学

• 矢島 治明

  京大・薬

• 矢島 治明

  Faculty Of Pharmaceutical Sciences Kyoto University

• 赤路 健一

  Faculty Of Pharmaceutical Sciences Kyoto University

関連論文

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