Synthesis of the Nonacosapeptide corresponding to Mammalian Glucagon
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概要
- 論文の詳細を見る
The nonacosapeptide corresponding to the entire amino acid sequence of mammalian glucagon was synthesized via the corresponding sulfoxide, [Met (O)^<27>]-glucagon. For synthesis of the protected nonacosapeptide six subunits were prepared to serve for building blocks. The condensations of subunits were achieved by the HONB-DCC method. Finally, all the protecting groups of the protected peptide were removed by the treatment with methanesulfonic acid-anisole to give [Met (O)^<27>]-glucagon. The sulfoxide was then treated with 3% aqueous thioglycolic acid to give mammalian glucagon. The product was successfully crystallized from dilute aqueous sodium chloride solution. The N to O acyl migration of serine and threonine residues with methanesulfonic acid treatment was studied in detail.
- 社団法人日本薬学会の論文
- 1978-02-25
著者
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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藤野 政彦
武田薬品工業
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藤野 政彦
武田薬品中央研
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北田 千恵子
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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北田 千恵子
Discovery Research Division Takeda Chemical Industries Ltd.
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Kitada Chieko
Discovery Research Division Takeda Chemical Industries Ltd
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脇舛 光広
Chemistry Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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脇舛 光広
Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.
関連論文
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