SYNTHESIS OF A 42 RESIDUE PEPTIDE CORRESPONDING TO THE ENTIRE AMINO ACID SEQUENCE OF HUMAN GIP

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概要

• 論文の詳細を見る

• Human GIP (gastric inhibitory polypeptide or glucose-dependent insulinotropic polypeptide) was synthesized in a conventional solution method by assembling eight peptide fragments followed by deprotection with 1 M trifluoromethanesulfonic acid-thioanisole in trifluoroacetic acid. New amino acid derivatives, Trp (Mts), Asp (OChp), and Glu (OChp) [Mts=mesitylenesulfonyl, Chp=cycloheptyl] were employed to suppress various side reactions. Synthetic GIP exhibited a significant increase of immunoreactive insulin level in dog plasma under basal ground infusion of glucose.

• 社団法人日本薬学会の論文
• 1985-08-25

著者

• 細谷 亮

  京都大学第一外科

• 矢島 治明

  Faculty of Pharmaceutical Sciences, Kyoto University

• 水田 和彦

  First Department Of Internal Medicine Faculty Of Medicine:kyoto University

• 桜井 満也

  Exploratory Chemistry Research, Sankyo Co., Ltd.,

• 野水 基義

  Faculty of Pharmaceutical Sciences

• 桜井 満也

  Exploratory Chemistry Research Sankyo Co. Ltd.

• 森賀 本幸

  First Department of Internal Medicine, Faculty of Medicine

• 戸部 隆吉

  First Department of Surgery, Faculty of Medicine

• 野水 基義

  Faculty Of Pharmaceutical Sciences Kyoto University

• 矢島 治明

  京都大学

• 矢島 治明

  京大・薬

• 藤井 信孝

  京大 薬

• 矢島 治明

  Faculty Of Pharmaceutical Sciences Kyoto University

• 赤路 健一

  Faculty Of Pharmaceutical Sciences Kyoto University

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