Studies on Peptides. XVI. Regeneration of Lysine from N^ε-Formyllysine by Aqueous Hydrazine or Hydroxylamine and Their Application to the Synthesis of α-Melanocyte-stimulating Hormone
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概要
- 論文の詳細を見る
Treatment of N^ε-formyllysine with dilute aqueous hydrazine acetate or hydroxylamine hydrochloride in aqueous pyridine regenerated lysine in satisfactory yield. These methods were adopted to convert N^α-acetylseryltyrosylserylmethionylglutamylhistidylphenyl-alanylarginyltryptophylglycyl-N^ε-formyllysylprolylvaline amide to α-melanocyte-stimulating hormone (MSH). The products prepared by two alternate methods behaved quite identically with natural α-MSH on paper and thin-layer chromatographies and their infrared spectra were both identical with that of natural α-MSH. Their in vitro MSH activities were 2.3-5.4×10^<12> and 2.4-4.1×10^<12> U/g respectively.
- 社団法人日本薬学会の論文
- 1968-05-25
著者
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岡田 芳男
Faculty of Pharmaceutical Sciences Kobe-Gakuin University
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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川崎 紘一
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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南 英男
Faculty of Pharmaceutical Sciences, Kyoto University
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久保 一雄
Faculty of Pharmaceutical Sciences, Kyoto University
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山下 一郎
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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久保 一雄
Faculty Of Pharmaceutical Sciences Kyoto University
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南 英男
Faculty Of Pharmaceutical Sciences Kyoto University
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Kawasaki Keiko
Biological Science Laboratories Kao Corporation
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川崎 紘一
Faculty Of Pharmaceutical Sciences & Cooperative Research Center Of Life Sciences Kobe Gakuin Un
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山下 一郎
Faculty Of Pharmaceutical Sciences Kyoto University
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