Amino Acids and Peptides. XL. Synthesis of Ac-Tyr-Val-Ala-Asp-MCA Using Newly Developed Acetylating Reagent

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概要

• 論文の詳細を見る

• 2-Acetoxy-3-benzyl-5-methyl-6-isobutylpyrazine was prepared by cyclization of H-Phe-Leu-CH_2Cl, followed by acetylation with acetic anhydride. This pyrazine derivative can react with amino groups of amino acids or peptides to produce acetyl amino acids or acetyl peptides without acetylation of hydroxy group of Tyr, Ser and Thr. Using this acetylating reagent, Ac-Tyr-Val-Ala-Asp-MCA, which is a specific substrate of the interleukin-I (IL-I) processing enzyme, was prepared.

• 社団法人日本薬学会の論文
• 1995-08-15

著者

• 岡田 芳男

  Faculty of Pharmaceutical Sciences Kobe-Gakuin University

• 浅田 圭一

  Faculty of Pharmaceutical Sciences Kobe-Gakuin University

• 横井 利夫

  Faculty of Pharmaceutical Sciences, Kobe-Gakuin University

• 平野 健一

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• 岡田 芳男

  神戸学院大学 薬学部

• 田口 博明

  Faculty of Pharmaceutical Sciences, Kobe-Gakuin University

• 田口 博明

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• 横井 利夫

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• Yokoi T

  Kobe‐gakuin Univ. Hyogo Jpn

• Asada K

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

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