Amino Acids and Peptide. XXX. Synthesis of Eglin c (41-49) and Eglin c (60-63) and Examination of Their Inhibitory Activity towards Human Leukocyte Elastase, Cathepsin G, Porcine Pancreatic Elastase and α-Chymotrypsin

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概要

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• H-Ser-Pro-Val-Thr-Leu-Asp-Leu-Arg-Tyr-OH and H-Thr-Asn-Val-Val-OH, which correspond to the sequences 41-49 and 60-63 of eglin c, respectively, were synthesized by a conventional solution approach using the newly developed 6-chloro-2-pyridyl ester method. The inhibitory activities of the above two peptides against human leukocyte elastase, cathepsin G, porcine pancreatic elastase and α-chymotrypsin were examined in comparison with those of the corresponding methyl esters.

• 社団法人日本薬学会の論文
• 1991-01-25

著者

• 岡田 芳男

  Faculty of Pharmaceutical Sciences Kobe-Gakuin University

• 永松 陽子

  Faculty Of Nutrition Kobe-gakuin University

• 坪井 諭志

  Faculty of Pharmaceutical Sciences Kobe-Gakuin University

• 山本 順一郎

  Faculty of Nutrition, Kobe-Gakuin University

• 武田 美帆

  Faculty of Pharmaceutical Sciences Kobe-Gakuin University

• 岡田 芳男

  神戸学院大学 薬学部

• 山本 順一郎

  Faculty Of Nutrition Kobe-gakuin University

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