Synthesis of Stereoisomeric Suc-Tyr-Leu-Val-pNA and Their Properties as Substrate and Inhibitor for Human Spleen Fibrinolytic Proteinase (SFP)

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概要

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• Stereoisomeric analogues of Suc-Tyr-Leu-Val-pNA were synthesized in the conventional manner and their properties as the substrate and/or the inhibitor against human spleen fibrinolytic proteinase (SFP) were tested. Suc-D-Tyr-L-Leu-L-Val-pNA (II) was hydrolyzed to release p-nitroaniline with K_<eat>/K_m value (3700), whereas K_<eat>/K_m value of Suc-L-Tyr-L-Leu-L-Val-pNA (I) was 22647. Suc-L-Tyr-D-Leu-D-Val-pNA (III) inhibited the hydrolytic activity of SFP towards both the peptide (I) and fibrin.

• 社団法人日本薬学会の論文
• 1981-05-23

著者

• 岡田 芳男

  Faculty of Pharmaceutical Sciences Kobe-Gakuin University

• 津田 裕子

  Faculty of Pharmaceutical Sciences

• 永松 陽子

  Faculty Of Nutrition Kobe-gakuin University

• 岡本 歌子

  Faculty of Pharmaceutical Sciences

• 津田 裕子

  神戸学院大学薬学部薬品化学

• 岡本 歌子

  血栓止血研究神戸プロジェクト

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