Amino Acids and Peptides. XXII. : Synthesis of Substrates and Inhibitors of Human Leukocyte Cathepsin G

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概要

• 論文の詳細を見る

• Suc-Try-Leu-Phe-pNA is a good substrate for human leukocyte cathepsin G and α-chymotrypsin but not for human leukocyte elastase (HLE). However, Suc-Tyr-D-Leu-D-Phe-pNA inhibited not only cathepsin G and α-chymotrypsin but also HLE (K_i values, 1.1,0.94 and 0.16 mM, respectively). The p-nitroanilide (pNA) moiety of Suc-Tyr-Leu-Phe-pNA and Suc-Tyr-D-Leu-D-Phe-pNA was substituted with p-benzoylaniline (BZA), p-acetylaniline (ACA), 4-benzylpiperidine (BPP) and 4-methylpiperidine (Pipe). The relationship between the structure and inhibitory effect on HLE, cathepsin G and α-chymotrypsin was studied. Such-Tyr-Leu-Phe-BZA inhibited HLE, cathepsin G and α-chymotrypsin with K_i values of 0.027,0.1 and 0.1 mM, respectively.

• 社団法人日本薬学会の論文
• 1988-12-25

著者

• 岡田 芳男

  Faculty of Pharmaceutical Sciences Kobe-Gakuin University

• 津田 裕子

  Faculty of Pharmaceutical Sciences

• 永松 陽子

  Faculty Of Nutrition Kobe-gakuin University

• 手納 直規

  Faculty of Pharmaceutical Sciences

• 永松 陽子

  Nutrition

• 岡本 歌子

  Nutrition

• 津田 裕子

  神戸学院大学薬学部薬品化学

• 岡田 芳男

  神戸学院大学 薬学部

• 手納 直規

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• 岡本 歌子

  血栓止血研究神戸プロジェクト

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