Amino Acids and Peptides. XXIX. Synthesis of Peptide Fragments Related to Active Center of Eglin c and Studies on the Relationship between Their Structure and Their Inhibitory Activity against Cathepsin G and α-Chymotrypsin

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概要

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• H-Ser-Pro-Val-Thr-Leu-Asp-Leu-Arg-Tyr-OMe, corresponding to the sequence 41-49 of eglin c, inhibited human leukocyte cathepsin G and α-chymotrypsin. In order to gain further insight into the relationship between the structure and the inhibitory activity against cathepsin G and α-chymotrypsin, peptide fragments related to the above nonapeptide were synthesized by a conventional solution method and their inhibitory activities were examined. The smallest peptide which exhibited inhibitory effects on the above envymes was H-Pro-Val-Thr-Leu-OMe, corresponding to the sequence 42-45 of eglin c.

• 社団法人日本薬学会の論文
• 1990-12-25

著者

• 岡田 芳男

  Faculty of Pharmaceutical Sciences Kobe-Gakuin University

• 永松 陽子

  Faculty Of Nutrition Kobe-gakuin University

• 坪井 諭志

  Faculty of Pharmaceutical Sciences Kobe-Gakuin University

• 山本 順一郎

  Faculty of Nutrition, Kobe-Gakuin University

• 中林 和則

  Faculty of Pharmaceutical Sciences, Kobe-Gakuin University

• 藤本 泰造

  Faculty of Pharmaceutical Sciences, Kobe-Gakuin University

• 岡田 芳男

  神戸学院大学 薬学部

• 藤本 泰造

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• 山本 順一郎

  Faculty Of Nutrition Kobe-gakuin University

• 中林 和則

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

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