Inhibition of α-Chymotrypsin by Suc-L-Tyr-D-Leu-D-Phe-pNA, a Stereoisomer of a Specific Substrate

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概要

• 論文の詳細を見る

• Stereoisomers of specific chromogenic substrates for various enzymes were synthesized by a conventional solution method. Among them, Suc-L-Tyr-D-Leu-D-Phe-pNA was found to be an effective and specific inhibitor of α-chymotrypsin. However, Suc-L-Tyr-D-Leu-D-Phe-Pipe did not show any inhibitory effect on α-chymotrypsin. The role of the pNA moiety of the above stereoisomer was investigated, and it was found that the pNA moiety participated in binding with some part of the enzyme, resulting in the manifestation of the inhibitory activity.

• 社団法人日本薬学会の論文
• 1985-12-25

著者

• 岡田 芳男

  Faculty of Pharmaceutical Sciences Kobe-Gakuin University

• 津田 裕子

  Faculty of Pharmaceutical Sciences

• 永松 陽子

  Faculty Of Nutrition Kobe-gakuin University

• 手納 直規

  Faculty of Pharmaceutical Sciences

• 岡本 歌子

  Faculty of Pharmaceutical Sciences

• 西 則雄

  Kobe-Gakuin University Faculty of Science, Hokkaido University

• 津田 裕子

  神戸学院大学薬学部薬品化学

• 手納 直規

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• 岡本 歌子

  血栓止血研究神戸プロジェクト

• 西 則雄

  Faculty Of Science Hokkaido University

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