Amino Acids and Peptides. XXV. : Application of Newly Developed β-1- and β-2-Adamantylaspartates to Peptide Synthesis by Solid Phase and Conventional Solution Methods

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概要

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• Newly developed β-1- and β-2-adamantylaspartates [H-Asp(O-1-Ada)-OH and H-Asp(O-2-Ada)-OH] were applied to the sythesis of a C-terminal octapeptide of the β-subunit of human chorionic gonadotropin (hCG) by a conventional solution method and a hexacosapeptide of the α-subunit of insulin receptor (30-55) by a solid-phase method with the objective of suppressing aspartimide formation during the synthesis of aspartylpeptides. The 1-Ada and 2-Ada groups were confirmed to be useful protecting groups for the β-carboxyl function of the Asp residue.

• 社団法人日本薬学会の論文
• 1989-08-25

著者

• 岡田 芳男

  Faculty of Pharmaceutical Sciences Kobe-Gakuin University

• 津田 裕子

  Faculty of Pharmaceutical Sciences

• 井口 伸

  Faculty of Pharmaceutical Sciences

• 津田 裕子

  神戸学院大学薬学部薬品化学

• 岡田 芳男

  神戸学院大学 薬学部

• 井口 伸

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

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