Studies on Peptides. XXIII. Total Synthesis of Monkey β-Melanocyte-stimulating Hormone

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概要

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• Total synthesis of monkey β-melanocyte-stimulating hormone was described. The synthesis involved in the coupling reaction of N^a-t-butoxycarbonyl-β-t-butylaspartyl-γ-t-butylglutamylglycine with prolyltyrosylarginylmethionylglutamylhistidylphenylalanylarginyltryptophylglycylserylprolylprolyl-N^ε-formyllysylaspartic acid by the N-hydroxysuccinimide ester method and subsequent removal of all of the protecting groups from the product, i. e., t-butyl and t-butoxycarbonyl groups by trifluoroacetic acid and the formyl group by hydrazine acetate. Synthetic monkey β-MSH exhibited 6×10^9 and 2.5×10^<10>MSH U/g.

• 社団法人日本薬学会の論文
• 1969-06-25

著者

• 岡田 芳男

  Faculty of Pharmaceutical Sciences Kobe-Gakuin University

• 矢島 治明

  Faculty of Pharmaceutical Sciences, Kyoto University

• 溝上 業彬

  Faculty of Pharmaceutical Sciences, Kyoto University

• 木野村 保彦

  Faculty of Pharmaceutical Sciences, Kyoto University

• 河谷 紘樹

  Faculty of Pharmaceutical Sciences, Kyoto University

• 溝上 業彬

  Central Research Division Takeda Chemical Industries Ltd.

• 矢島 治明

  Faculty Of Pharmaceutical Sciences Kyoto University

• 木野村 保彦

  Faculty Of Pharmaceutical Sciences Kyoto University

関連論文

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