Studies on Peptides. LXXIX. : By-Products derived from N^α-Protected Tryptophan by Acids
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概要
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Four by-products formed during the treatment of Z (OMe)-Trp-OH with trifluoroacetic acid were isolated and their structures were assigned by nuclear magnetic resonance and mass spectra. It was found that the major by-product was H-Trp (2'-p-methoxybenzyl)-OH. Confirmatively, H-Trp (1'-tert-butyl)-OH was identified as the major by-product from Boc-Trp-OH. Such side reaction was found to be efficiently suppressed by the use of the scavenger system, such as, thioanisole containing 2% ethanedithiolskatole or dimethylsulfide containing 2% ethanedithiol-skatole, during the deprotection with trifluoroacetic acid or preferably with 4N ethanesulfonic acid.
- 社団法人日本薬学会の論文
- 1978-10-25
著者
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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小川 博
Faculty Of Pharmaceutical Sciences Kyoto University
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入江 寛
Faculty of Pharmaceutical Sciences, Nagasaki University
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佐々木 敬
Research Institute Daiichi Seiyaku Co. Ltd.
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佐々木 敬
Faculty of Pharmaceutical Sciences, Kyoto University
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入江 寛
長崎大学薬学部
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入江 寛
Faculty Of Pharmaceutical Sciences Kyoto University
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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