Studies on Peptides. CLVII. : Synthesis of a Frog-Skin Peptide, Sauvagine
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概要
- 論文の詳細を見る
A tetracontapeptide corresponding to the entire amino acid sequence of a frog skin peptide, sauvagine, was synthesized by assembling eight peptide fragments of established purity followed by deprotection with 1 M trimethylsilyl trifluoromethanesulfonate-thioanisole in trifluoroacetic acid. The synthetic peptide stimulated secretion of immunoreactive corticotropin from rat pituitary cells and its potency was estimated to be equivalent to that of synthetic ovine corticotropin releasing factor. Synthetic sauvagine displayed long-lasting hypotensive action in rats.
- 公益社団法人日本薬学会の論文
- 1988-01-25
著者
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藤井 信孝
京都大学薬学部
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仲田 義啓
広島大学大学院 医歯薬学総合研究科 薬効解析科学
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藤井 信孝
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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井上 敦子
Faculty Of Pharmaceutical Sciences School Of Medicine Hiroshima University
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野水 基義
Faculty of Pharmaceutical Sciences
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赤路 健一
Faculty of Pharmaceutical Sciences
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野水 基義
Faculty Of Pharmaceutical Sciences Kyoto University
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深田 順一
京大 医
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矢島 治明
京都大学
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矢島 治明
京大・薬
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藤井 信孝
京大 薬
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深田 順一
the 2nd Internal Medicine, Faculty of Medicine, Kyoto University
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井村 裕夫
the 2nd Internal Medicine, Faculty of Medicine, Kyoto University
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仲田 義啓
Faculty of Pharmaceutical Sciences, School of Medicine, Hiroshima University
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瀬川 富朗
Faculty of Pharmaceutical Sciences, School of Medicine, Hiroshima University
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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瀬川 富郎
Faculty Of Pharmaceutical Sciences School Of Medicine Hiroshima University
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井村 裕夫
The 2nd Internal Medicine Faculty Of Medicine Kyoto University
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藤井 信孝
京都大学
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赤路 健一
Faculty Of Pharmaceutical Sciences Kyoto University
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仲田 義啓
広島大学医学部総合薬学科
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