シスチン含有ペプチドの新規合成法
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概要
- 論文の詳細を見る
In terms of the efficient and/or unambiguous synthesis of complex peptides (proteins) containing several cystine residues, the existing methods are still less than satisfactory. Therefore one of our research interests has been focused on methodological improvements for the chemical synthesis of cystine peptides. We developed two new disulfide bond forming reactions; the one by thallium (III) oxidation and the other by acid catalyzed reaction involving S-protected cysteine sulfoxides, in addition developed a new S-deprotecting method by using AgOTf. We wish to describe three methods above mentioned and the applications for the syntheses of cystine-containing peptides.
- 社団法人 有機合成化学協会の論文
著者
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藤井 信孝
京都大学薬学部
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大高 章
徳島大学大学院ヘルスバイオサイエンス研究部
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大高 章
京都大学 薬
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藤井 信孝
京都大学大学院薬学研究科 医薬創成情報科学専攻
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藤井 信孝
京都大学薬学研究科
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大高 章
京大 大学院薬学研究科
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大高 章
京都大学薬学部
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