Studies on Peptides. CXLIX. : Solid-Phase Synthesis of a Rabbit Stomach Peptide by Application of a New Polymer Support and a New Deprotecting Procedure(Organic,Chemical)
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概要
- 論文の詳細を見る
A newly found rabbit stomach peptide, H-Pyr-Val-Asp-Pro-Asn-Ile-Gln-Ala-OH, was synthesized by the solid-phase method. A new polymer support, cross-linked polystyrene-polypropylene composite fiber (IONEX), was employed to facilitate multiple washing processes in chain elongation reactions. β-Cycloheptyl aspartate, Asp(OChp), was employed for the first time in this solid-phase peptide synthesis. In the final step of the synthesis, the peptide was cleaved from the resin, together with other protecting groups employed, by treatment with IM trimethylsilyl trifluoromethanesulfonatethioanisole in trifluoroacetic acid. The deprotected peptide was found to be identical with the sample obtained from the natural source.
- 公益社団法人日本薬学会の論文
- 1987-03-25
著者
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藤井 信孝
京都大学薬学部
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藤井 信孝
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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船越 奨
Faculty of Pharmaceutical Sciences
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赤路 健一
Faculty of Pharmaceutical Sciences
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矢島 治明
京都大学
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船越 奨
Faculty Of Pharmaceutical Sciences Kyoto University
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矢島 治明
京大・薬
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藤井 信孝
京大 薬
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林 良雄
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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Lazarus Lawrence
Japan And National Institute Of Environmental Health Sciences
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藤井 信孝
京都大学
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赤路 健一
Faculty Of Pharmaceutical Sciences Kyoto University
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島村 政治
Fiber Research Laboratories, Toray Industries, Inc.
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柚口 貞夫
Showa Industry Co., Ltd.
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柚口 貞夫
Showa Industry Co. Ltd.
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島村 政治
Fiber Research Laboratories Toray Industries Inc.
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林 良雄
Faculty Of Pharmaceutical Sciences Kyoto University
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