Studies on Peptides. CXIX. Synthesis of Growth Hormone Releasing Factor (hpGRF-40-OH)
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概要
- 論文の詳細を見る
The tetracontapeptide corresponding to the entrie amino acid sequence of growth hormone releasing factor (hpGRF-40-OH) was synthesized by fragment condensation in solution, followed by deprotection with 1M trifluoromethanesulfonic acid-thioanisole in trifluoroacetic acid. In in vivo assay, synthetic hpGRF-40-OH was as active as synthetic hpGRF-44-NH_2,but in in vitro assay, the potency of synthetic hpGRF-40-OH was only 36% of that of synthetic hpGRF-44-NH_2.
- 公益社団法人日本薬学会の論文
- 1984-03-25
著者
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藤井 信孝
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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吉武 彬
Institute For Biological Sciences Sumitomo Chemical Co. Ltd.
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庄野 文章
Institute For Biological Sciences Sumitomo Chemical Co. Ltd.
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庄野 文章
住友化学工業
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矢島 治明
京都大学
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矢島 治明
京大・薬
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藤井 信孝
京大 薬
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霜倉 正徳
Faculty of Pharmaceutical Sciences, Kyoto University
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津田 正文
Institute for Biological Sciences, Sumitomo Chemical Co., Ltd.
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津田 正文
Research laboratories, Sumitomo Pharmaceuticals Co., Ltd.,
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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霜倉 正徳
Department of Medicinal Chemistry, Kyoto Pharmaceutical University
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霜倉 正徳
Department Of Medicinal Chemistry Kyoto Pharmaceutical University
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津田 正文
Research Laboratories Sumitomo Pharmaceuticals Co. Ltd.
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