Studies on Peptides. CXXXIV. : Evaluation of S-1-Adamantylcysteine for Peptide Synthesis

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概要

• 論文の詳細を見る

• The S-1-adamantyl (Ad) group of cysteine is more stable to TFA treatment than the S-p-methoxybenzyl (MBzl) group, but is cleavable by 1 M trifluoromethanesulfonic acid-thioanisole in trifluoroacetic acid at 0℃ within 60 min or by (CF_3COO)_3 Tl under similar conditions. S-Ad-cysteine is less susceptible to sulfoxide formation than the S-MBzl group. Trimethylphenyl-thiosilane is an effective reducing reagent of the sulfoxide.

• 社団法人日本薬学会の論文
• 1986-02-25

著者

• 藤井 信孝

  京都大学薬学部

• 西村 紀

  Chemical Research Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 大高 章

  Faculty of Pharmaceutical Sciences, Kyoto University

• 藤井 信孝

  Faculty of Pharmaceutical Sciences, Kyoto University

• 矢島 治明

  Faculty of Pharmaceutical Sciences, Kyoto University

• 藤野 政彦

  Pharmaceutical Research Division Takeda Chemical Industries Ltd.

• 藤野 政彦

  武田薬品工業

• 藤野 政彦

  Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 船越 奨

  Faculty of Pharmaceutical Sciences

• 大高 章

  京都大学 薬

• 藤野 政彦

  武田薬品中央研

• 藤野 政彦

  武田薬品工業(株)

• 矢島 治明

  京都大学

• 船越 奨

  Faculty Of Pharmaceutical Sciences Kyoto University

• 矢島 治明

  京大・薬

• 藤井 信孝

  京大 薬

• 矢島 治明

  Faculty Of Pharmaceutical Sciences Kyoto University

• 藤井 信孝

  京都大学

• Fujino M

  Pharmaceutical Research Division Takeda Chemical Industries Ltd

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