The Use of N-Hydroxy-5-norbornene-2,3-dicarboximide Active Esters in Peptide Synthesis

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概要

• 論文の詳細を見る

• N-Hydroxy-5-norbornene-2,3-dicarboximide (HONB) was found to be an excellent reagent to be used in couple with N, N'-dicyclohexylcarbodiimide (DCC) for the peptide synthesis. Various racemization tests by the use of this reagent were conducted to see the degree of racemization during the peptide synthesis. The newly employed reagent (HONB) decreases racemization, prohibits formation of N-acylurea and affords peptides in excellent yields and a high state of purity. To evaluate this new reagent, luteinizing hormone releasing hormone (LH-RH) was prepared by the new active ester method.

• 社団法人日本薬学会の論文
• 1974-08-25

著者

• 西村 紀

  Chemical Research Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 藤野 政彦

  Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 福田 常彦

  Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 大林 幹彦

  Central Research Division, Takeda Chemical Industries, Ltd.

• 大林 幹彦

  Central Research Division Takeda Chemical Industries Ltd.

• 藤野 政彦

  武田薬品中央研

• 西村 紀

  Medical Research Laboratory, Takeda Chemical Ind. Ltd.

• 藤野 政彦

  Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 小林 栄

  Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 大林 幹彦

  Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 福田 常彦

  Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 品川 進

  Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

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