Synthesis of the Nonatetracontapeptide corresponding to the Sequence proposed for Thymopoietin II
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概要
- 論文の詳細を見る
First total synthesis of a nonatetracontapeptide corresponding to the entire amino acid sequence of thymopoietin II, a T cell differentiating hormone isolated from bovine thymus, was described. Toward the synthesis of this hormone, two relatively large fragments corresponding to the sequence 1-27 and 28-49 were prepared and the fragments were served as the building blocks for the final construction of the entire amino acid sequence of the hormone. The final deprotection of the fully protected nonatetracon-tapeptide was achieved by the treatment with methanesulfonic acid or hydrogen fluoride, and the purification of the synthetic peptide was effected by a column chromatography on Sephadex G-50,Biogel P-2 and CM-cellulose. The physicochemical and biological properties of the synthetic peptide were also described.
- 公益社団法人日本薬学会の論文
- 1977-06-25
著者
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藤野 政彦
武田薬品工業
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高沖 宗夫
Central Research Division Takeda Chemical Industries Ltd.
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福田 常彦
Central Research Division, Takeda Chemical Industries, Ltd.
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福田 常彦
Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.
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藤野 政彦
武田薬品中央研
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藤野 政彦
Central Research Division, Takeda Chemical Industries Ltd.
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杉野 幸夫
Central Research Division Takeda Chemical Industries Ltd.
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品川 進
Central Research Division, Takeda Chemical Industries, Ltd.
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川路 尚徳
Central Research Division, Takeda Chemical Industries, Ltd.
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川路 尚徳
Central Research Division Takeda Chemical Industries Ltd.
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