Use of the 4-Methoxy-2,6-dimethylbenzenesulfonyl (Mds) Group to Synthesize Dynorphin [1-13] and Related Peptides
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概要
- 論文の詳細を見る
The syntheses of a tridecapeptide corresponding to the amino acid sequence of dynorphin [1-13], H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH, and related truncated peptides, [4-13], [8-11], and [8-13], using the 4-methoxy-2,6-dimethylbenzenesulfonyl (Mds) group for the protection of the guanidino function of arginine, are described. To synthesize dynorphin [1-13], three fragments, 1-3,4-10,and 11-13,were prepared and used as building blocks for the final construction of the amino acid sequence of this peptide. Final deprotection of the fully protected peptide was achieved by treatment with trifluoroacetic acid-thioanisole at 50℃ for 2 h and the purification of this synthetic peptide was effected by column chromatography on CM-cellulose. Other truncated peptides, [4-13], [8-11], and [8-13], were synthesized in the same manner as described for dynorphin [1-13]. The applicability of the Mds protecting group for the synthesis of arginine-containing peptides was confirmed.
- 社団法人日本薬学会の論文
- 1981-09-25
著者
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藤野 政彦
Pharmaceutical Research Division Takeda Chemical Industries Ltd.
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藤野 政彦
武田薬品工業
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藤野 政彦
Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.
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藤野 政彦
武田薬品中央研
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北田 千恵子
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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藤野 政彦
武田薬品工業(株)
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北田 千恵子
Discovery Research Division Takeda Chemical Industries Ltd.
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Kitada Chieko
Discovery Research Division Takeda Chemical Industries Ltd
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脇舛 光廣
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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脇舛 光廣
Chemical Research Laboratories Central Research Division Takeda Chemical Industries Ltd.
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