Synthesis of Some Di-and Tri-Substituted Analogs of Luteinizing Hormone Releasing Hormone (LH-RH)

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概要

• 論文の詳細を見る

• Eight new di- and tri-substituted luteinizing hormone releasing hormone (LH-RH) analogs, i.e., des-Gly^<10>-[Thr^4]-LH-RH-ethylamide, des-Gly^<10>-[Phe^5]-LH-RH-ethylamide, des-Gly^<10>-[Phe^5,Ile^7]-LH-RH-ethylamide, des-Gly^<10>-[Nle^7]-LH-RH-ethylamide, des-Gly^<10>-[Met^7]-LH-RH-ethylamide, des-Gly^<10>-[Orn^8]-LH-RH-ethylamide, des-Gly^<10>-[Lys^8]-LH-RH-ethylamide and des-Gly^<10>-[Gly^9]-LH-RH-ethylamide, were synthesized by the solution method, and tested in vitro for the ability to induce secretion of luteinizing hormone. On the basis of structure-activity relations of these analogs, it is concluded that the effect of several structural changes in the LH-RH-molecule on its hormonal activity is"additive".

• 社団法人日本薬学会の論文
• 1975-09-25

著者

• 藤野 政彦

  武田薬品工業

• 福田 常彦

  Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 大林 幹彦

  Central Research Division, Takeda Chemical Industries, Ltd.

• 大林 幹彦

  Central Research Division Takeda Chemical Industries Ltd.

• 藤野 政彦

  武田薬品中央研

• 藤野 政彦

  Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 大林 幹彦

  Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 福田 常彦

  Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 品川 進

  Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 小林 榮

  Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

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