Synthesis of Granuliberin-R and Various Fragment Peptides and Their Histamine-Releasing Activities

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概要

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• Granuliberin-R and various fragment peptides were synthesized and their histaminereleasing activities were examined. The relative potencies of granuliberin-R, H-Phe-Gly-Phe-Leu-Pro-Ile-Tyr-Arg-Arg-Pro-Ala-Ser-NH_2,as liberators of histamine from mast cells are very similar to those of substance P and bradykinin. Studies on the histamine-releasing activity of various fragment peptides of granuliberin-R showed that a 4-amino acid central sequence, -Ile-Tyr-Arg-Arg-, is the minimum requirement for the releasing action of this frog skin peptide.

• 社団法人日本薬学会の論文
• 1980-03-25

著者

• 牧 良孝

  武田薬品中央研究所生物研

• 矢島 治明

  Faculty of Pharmaceutical Sciences, Kyoto University

• 安原 義

  東京農大

• 藤野 政彦

  Pharmaceutical Research Division Takeda Chemical Industries Ltd.

• 藤野 政彦

  武田薬品工業

• 武山 正治

  Department of Clinical Pharmacy, Oita Medical University

• 中嶋 暉躬

  Institute of Pharmaceutical Sciences, School of Medicine, Hiroshima University

• 中嶋 暉躬

  東京大学薬学部薬品分析化学教室

• 平井 裕子

  広島大学医学部総合薬学科

• 藤野 政彦

  武田薬品中央研

• 藤野 政彦

  Central Research Division, Takeda Chemical Industries Ltd.

• 武山 正治

  Department Of Clinical Pharmacy Oita Medical University

• 藤野 政彦

  武田薬品工業(株)

• 北田 千恵子

  Discovery Research Division Takeda Chemical Industries Ltd.

• Kitada Chieko

  Discovery Research Division Takeda Chemical Industries Ltd

• 矢島 治明

  Faculty Of Pharmaceutical Sciences Kyoto University

• 牧 良孝

  武田薬品中央研

• 芦田 康子

  武田薬品工業株式会社研究開発本部・生物研究所

• 芦田 康子

  武田薬品工業

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