Studies on Peptides. CLXVI. : Solid-Phase Syntheses and Immunological Properties of Fragment Peptides Related to Human Hepatitis B Virus Surface Antigen (HBsAg) and Its Pre-S2 Gene
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概要
- 論文の詳細を見る
Enght fragment peptides of 25 residuse each and one 26-residue fragment, covering the entire 226 amino acid sequence of human hepatitis surface antigen (HBsAg, subtype ayw), were synthesized by the solid-phase method and partially purified by gel-filtration. In addition, two fragment peptides (26- and 29-residue peptides) which cover the 55 amino acid sequence encoded in the pre-S2 gene were also synthesized and partially purified. These partially purified peptides were submitted to immunological screening. In the in vitro enzyme linked immunoassay (ELISA), a 26-residue pre-S2 gene peptide (positions 1-26) exhibited relatively high reactivity against anti-HBsAg antisera. In the in vivo assay, three fragment peptides (positions 51-75,101-125,and pre-S2 1-26), with relatively high hydrophilicity were shown to be immunogenic in rabbit without coupling to a carrier protein.
- 公益社団法人日本薬学会の論文
- 1988-12-25
著者
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藤井 信孝
京都大学薬学部
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藤井 信孝
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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野水 基義
Faculty of Pharmaceutical Sciences
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片倉 晋一
Faculty of Pharmaceutical Sciences, Kyoto University
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野水 基義
Faculty Of Pharmaceutical Sciences Kyoto University
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見明 史雄
The Chemo-sero-therapeutic Research Institute
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桑田 茂喜
The Chemo-sero-therapeutic Research Institute
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矢島 治明
京都大学
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片倉 晋一
Research Institute, Daiichi Pharmaceutical Co., Ltd.,
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矢島 治明
京大・薬
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藤井 信孝
京大 薬
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林 良雄
Faculty of Pharmaceutical Sciences, Kyoto University
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田代 昭
The Chemo-Sero-Therapeutic Research Institute
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LIU TEH-YUNG
Office of Biologics Resarch and Review, Food and Drugs Administration
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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片倉 晋一
Research Institute Daiichi Pharmaceutical Co. Ltd.
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劉 徳勇
Office Of Biologics Research And Review Food And Drug Administration
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藤井 信孝
京都大学
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林 良雄
Faculty Of Pharmaceutical Sciences Kyoto University
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