Studies on Peptides. CLXII. : Synthesis of Chicken Calcitonin-Gene-Related Peptide (cCGRP) by Application of Sulfoxide-Directed Disulfide-Bond-Forming Reaction
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概要
- 論文の詳細を見る
A 37-residue peptide corresponding to the entire amino acid sequence of chicken calcitonin-gene-related peptide (cCGRP) was synthesized by successive assembling of seven peptide fragments via the azide, followed by acid treatments of protected cCGRP in two steps, i.e., first with trifluoroacetic acid (TFA) in the presence of diphenylsulfide to establish the disulfide bond between the Cys(MBzl) sulfoxide and the Cys(MBzl) residues (positions 2 and 7,respectively) and then with 1 M trimethylsilyl trifluoromethanesulfonate in TFA to remove the rest of the protecting groups employed. The synthetic peptide suppressed the ^<45>Ca release from mouse calvaria.
- 公益社団法人日本薬学会の論文
- 1988-09-25
著者
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藤井 信孝
京都大学薬学部
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大高 章
Faculty of Pharmaceutical Sciences, Kyoto University
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藤井 信孝
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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小西 淳二
Department of Nuclear Medicine, School of Medicine, Kyoto University
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山本 逸雄
Department Of Radiology School Of Medicine:kyoto University
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大高 章
徳島大学大学院ヘルスバイオサイエンス研究部
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大高 章
京都大学 薬
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大高 章
京大 大学院薬学研究科
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渡辺 俊博
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
京都大学
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矢島 治明
京大・薬
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藤井 信孝
京大 薬
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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青竹 環
Faculty of Pharmaceutical Sciences
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小西 淳二
Department Of Nuclear Medicine And Diagnostic Imaging Kyoto University Graduate School Of Medicine
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渡辺 俊博
Faculty Of Pharmaceutical Sciences:kyoto University
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青竹 環
Faculty Of Pharmaceutical Sciences:kyoto University
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小西 淳二
Department Of Nuclear Medicine School Of Medicine:kyoto University
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藤井 信孝
京都大学
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