Studies on Peptides. CXXXVIII. : Conventional Solution Synthesis of Bovine Hypothalamic Growth Hormone Releasing Factor (bGRF)
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概要
- 論文の詳細を見る
A 44 residue peptide amide corresponding to the entire amino acid sequence of bovine hypothalamic growth hormone releasing factor (bGRF) was synthesized by assembling nine peptide fragments via the azide followed by deprotection with 1M trifluoromethanesulfonic acid-thioanisole in trifluoroacetic acid. Met(O) was reduced by dimethylselenide during the above acid treatment. The synthetic peptide was as active as synthetic human GRF-44-NH_2 in vitro assay.
- 公益社団法人日本薬学会の論文
- 1986-05-25
著者
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藤井 信孝
京都大学薬学部
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藤井 信孝
Faculty of Pharmaceutical Sciences, Kyoto University
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木曽 良明
Department of Medicinal Chemistry, Kyoto Pharmaceutical University
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木曽 良明
Department Of Medicinal Chemistry Kyoto Pharmaceutical University
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関 等
住友製薬研究所
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長田 明彦
住友製薬研究所
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木曽 良明
Kyoto College of Pharmacy
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矢島 治明
京都大学
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矢島 治明
京大・薬
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藤井 信孝
京大 薬
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霜倉 正徳
Kyoto Pharmaceutical University
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長田 明彦
Research laboratories, Sumitomo Pharmaceuticals Co., Ltd.,
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津田 正文
Research laboratories, Sumitomo Pharmaceuticals Co., Ltd.,
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関 等
Research laboratories, Sumitomo Pharmaceuticals Co., Ltd.,
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甲斐 啓幸
Research laboratories, Sumitomo Pharmaceuticals Co., Ltd.,
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矢嶋 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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矢嶋 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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甲斐 啓幸
Research Laboratories Sumitomo Pharmaceuticals Co. Ltd.
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霜倉 正徳
Department of Medicinal Chemistry, Kyoto Pharmaceutical University
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藤井 信孝
京都大学
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霜倉 正徳
Department Of Medicinal Chemistry Kyoto Pharmaceutical University
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津田 正文
Research Laboratories Sumitomo Pharmaceuticals Co. Ltd.
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長田 明彦
Research Department, Pharmaceuticals Division, Sumitomo Chemical Co., Ltd.
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