Synthesis and Activity of a newly Isolated Analgesic Pentapeptide, Neo-kyotorphin

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概要

• 論文の詳細を見る

• A newly isolated bovine brain pentapeptide, Thr-Ser-Lys-Tyr-Arg (neo-kyotorphin), which contains the Tyr-Arg (kyotorphin) unit at its carboxyl terminal portion, was synthesized by using the TFMSA-TFA-thioanisole deprotecting procedure. The synthetic peptide exhibited dosedependent analgesic activity in mice at a level approximately equal to that of Leu-enkephalin.

• 社団法人日本薬学会の論文
• 1983-07-25

著者

• 北川 幸己

  徳島大学薬学部

• 北川 幸己

  Faculty of Pharmaceutical Sciences, Kyoto University

• 高木 博司

  京都大学薬学部

• 秋田 正

  Faculty of Pharmaceutical Sciences, Tokushima University

• 木曽 良明

  Department of Medicinal Chemistry, Kyoto Pharmaceutical University

• 木曽 良明

  Department Of Medicinal Chemistry Kyoto Pharmaceutical University

• 高木 博司

  Faculty Of Pharmaceutical Sciences Kyoto University

• 高木 博司

  京都大学

• 福井 潔

  京都大学薬学部

• 河合 伸之

  Faculty of Pharmaceutical Sciences, University of Tokushima

• 木曽 良明

  Faculty of Pharmaceutical Sciences, University of Tokushima

• 福井 潔

  Department of Pharmacology, Kagawa Medical School

• 天野 博夫

  Faculty of Pharmaceutical Sciences, Kyoto University

• 河合 伸之

  Faculty Of Pharmaceutical Sciences University Of Tokushima

• 天野 博夫

  Faculty Of Pharmaceutical Sciences Kyoto University

• 秋田 正

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• 北川 幸己

  Faculty Of Pharmaceutical Sciences University Of Tokushima

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