Solution Syntheses of Two Enkephalin-Containing Peptides, Peptide E and Dynorphin(1-24), Using N^<in>-(2,4,6-Triisopropylphenylsulfonyl)tryptophan

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概要

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• Two enkephalin-containing peptides, peptide E and dynorphin (1-24), were synthesized by conventional solution methods employing a new Trp derivative, N^<in>-(2,4,6-triisopropylphenylsulfonyl)tryptophan [Trp(Tps)]. All protecting groups employed including the Tps group were removed by treatment with 1 M trifluoromethanesulfonic acid (TFMSA)-thioanisole in trifluoroacetic acid (TFA) at the final steps of these syntheses. Subsequent purifications by Sephadex G-25 chromatography, CM-Biogel A ion exchange chromatography, and reversed-phase high-performance liquid chromatography afforded highly purified samples. Both synthetic peptide E and dynorphin (1-24) exhibited high in vitro opioid activity. The usefulness of this new tryptophan derivative for practical peptide synthesis was established through these syntheses of complex Trp-containing peptides.

• 公益社団法人日本薬学会の論文
• 1989-10-25

著者

• 木山 晋哉

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• 二木 史朗

  徳島大学薬学部

• 二木 史朗

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• 北川 幸己

  Faculty of Pharmaceutical Sciences, Kyoto University

• 川元 達彦

  Faculty of Pharmaceutical Sciences, Tokushima University

• 秋田 正

  Faculty of Pharmaceutical Sciences, Tokushima University

• 木曽 良明

  Department of Medicinal Chemistry, Kyoto Pharmaceutical University

• 木曽 良明

  Department Of Medicinal Chemistry Kyoto Pharmaceutical University

• 秋田 正

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• 北川 幸己

  Faculty Of Pharmaceutical Sciences University Of Tokushima

• 木曽 良明

  Kyoto College of Pharmacy

• 守時 英喜

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• 二木 史朗

  Faculty Of Pharmaceutical Sciences Kyoto University

• 川元 達彦

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

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