Fungal Metabolites. I. Isolation and Biological Activities of Hypelcins A and B (Growth Inhibitors against Lentinus edodes) from Hypocrea peltata

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概要

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• Two new peptide antibiotics, hypelcins A and B, were isolated from Hypocrea peltata, which is antagonistic to Lentinus edodes. Hypelcins A and B are linear peptides which include nine or ten residues of the abnormal amino acid α-aminoisobutyric acid (Aib) and an amino alcohol, L-leucinol. Hypelcin A was confirmed to be an amide of hypelcin B by chemical conversion. Hypelcin A showed antifungal and antibacterial activities, and contractile action on guinea pig ileum.

• 社団法人日本薬学会の論文
• 1984-05-25

著者

• 高石 喜久

  徳島大院薬

• 山下 貴司

  浜松ホトニクス(株)中央研究所

• 藤多 哲朗

  Faculty of Pharmaceutical Sciences, The University of Tokushima

• 高石 喜久

  Faculty of Pharmaceutical Sciences, The University of Tokushima

• 高石 喜久

  Faculty Of Pharmaceutical Science Tokushima University

• 藤多 哲朗

  Faculty Of Pharmaceutical Sciences Kyoto University

• 守時 英喜

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• 時本 景亮

  菌葦研

• 小川 正

  Department of Nutrition, School of Medicine, The University of Tokushima

• 時本 景亮

  The Tottori Mycological Institute

• 小川 正

  Department Of Nutrition School Of Medicine The University Of Tokushima

• 高石 喜久

  Faculty of Integrated Arts and Sciences, University of Tokushima

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