Antirheumatic Agents. III. Novel Methotrexate Derivatives Bearing an Indoline Ring and a Modified Ornithine or Glutamic Acid

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概要

• 論文の詳細を見る

• The synthesis, biological profile and structure-activity relationship of various methotrexate (MTX) derivatives bearing an indoline ring are described. In particlular, N^δ-(3-carboxyphenyl)-N^α-[1-[(2,4-diaminopteridin-6-yl)-methyl]indoline-5-ylcarbonyl]-L-glutamine (3d), compared to MTX, exhibited an enhanced anti-proliferative effect on human peripheral blood mononuclear cells obtained from healthy volunteers.

• 公益社団法人日本薬学会の論文
• 1997-07-15

著者

• 高石 喜久

  徳島大院薬

• Takeda Y

  Fac. Of Integrated Arts And Sciences Univ. Of Tokushima

• Takeda Y

  Faculty Of Integrated Arts And Sciences The University Of Tokushima

• Ohi Nobuhiro

  Fuji Gotemba Research Laboratories Chugai Pharmaceutical Co. Ltd.

• MATSUOKA Hiroharu

  Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd.,

• KATO Nobuaki

  Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd.,

• MIYAMOTO Katsuhito

  Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd.,

• MIHARA Masahiko

  Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd.,

• TAKEDA Yasuhisa

  Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd.,

• Kato N

  Fuji Gotemba Research Laboratories Chugai Pharmaceutical Co. Ltd.

• Miyamoto K

  Kyuoto Univ. Kyoto Jpn

• Mihara M

  Fuji Gotemba Research Laboratories Chugai Pharmaceutical Co. Ltd.

• Matsuoka H

  Santen Pharmaceutical Co. Ltd. Osaka Jpn

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