Synthesis of Phenoxyacetic Acid Derivatives as Highly Potent Antagonists of Gastrin/Cholecystokinin-B Receptors. II
スポンサーリンク
概要
- 論文の詳細を見る
A series of phenoxyacetanilide derivatives was synthesized and their antagonist activities for human gastrin/cholecystokinin (CCK)-B and CCK-A receptors were evaluated. Among the compounds synthesized, 2-[3-[3-[N-[2-(N-methyl-N-phenylcarbamoylmethoxy)phenyl]-N-(N-methyl-N-phenylcarbamoylmethyl)carbamoylmethyl]-ureido]phenyl]acetic acid (20i, DA-3934) exhibited high affinity for gastrin/CCK-B receptors and high selectivity over CCK-A receptors. DA-3934 and its methyl ester derivative inhibited pentagastrin-induced gastric acid secretion in rats in a dose-dependent manner.
- 公益社団法人日本薬学会の論文
- 1998-06-15
著者
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高石 喜久
徳島大院薬
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Takeda Y
Fac. Of Integrated Arts And Sciences Univ. Of Tokushima
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Takeda Y
Faculty Of Integrated Arts And Sciences The University Of Tokushima
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Honda Y
Kumamoto Univ. Kumamoto Jpn
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Honda Yuko
Institute For Solid State Physics The University Of Tokyo
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Honda Yuko
Dept. Biol. Sci. Ehime Univ.
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Ogihara Y
Nihon Pharmaceutical University
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Ogihara Yukio
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
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Ogihara Yukio
Faculty Of Pharmacy Meijo Universitv
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Ogihara Yukio
Graduate School Of Pharmaceutical Sciences Nagoya City University
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TABUCHI Yoshiaki
New Product Research Laboratories III Daiichi Pharmaceutical Co., Ltd.
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細上 徹
第一製薬株式会社 (東京研究開発センター) 探索第三研究所
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細上 徹
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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下東 義正
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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下東 義正
New Product Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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TAKEDA Yasuyuki
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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KAWAGOE Keiichi
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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YOKOMIZO Aki
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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YOKOMIZO Yoshihiro
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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HOSOKAMI Toru
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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SHIMOTO Yoshimasa
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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OGIHARA Yoshiyasu
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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HONDA Yuko
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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YOKOHAMA Shuichi
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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OTSUBO Rira
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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Tabuchi Y
Second Department Of Surgery Graduate School Of Medicine And Pharmaceutical Sciences University Of T
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Tabuchi Yoshiaki
New Product Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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Yokomizo Yoshihiro
New Product Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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Otsubo Rira
New Product Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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Yokomizo Aki
New Product Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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細上 徹
New Product Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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Kawada K
New Product Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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Yokohama S
New Product Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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