Different Generation of Inhibitors against Gallic Acid-Induced Apoptosis Produces Different Sensitivity to Gallic Acid
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概要
- 論文の詳細を見る
Gallic acid (3, 4, 5-trihydroxybenzoic acid), a naturally ocurring plant phenol, showed selective cytotoxicity against tumor cells with higher sensitivity than normal cells such as hepatocytes and keratinocytes. To elucidate the difference in sensitivity between normal and tumor cells to gallic acid, er studied whether the inhibitor of gallic acid-induced apoptosis existed or not. A serum-free conditioned medium, prepared from high density rat primary cultured hepatocytes and cytoplasm of hepatocytes, precented gallic acid-induced aoiotosis. In contrast, hepatomas and hepatic cell lines such as dRLh-84, PLC/PRF/5, HLE, and HUH and two other kinds of tumor cells, HeLa and KB, scarcely fenerated such an inhibitor in either their conditioned medium or their cells. Biochemical characterization of the inhibitors revealed that the inhibitor in the hepatocyte conditioned medium was completely inactivated by heating at 65℃ for 10min. Its molecular weight was estimated at 150-250kDa by gel filtration column chromatography, indicating that the inhibitor may be a protein-like substance. These results suggest that the generation of a large amount of the inhibitor may endow hepatocytes with insensitivity to gallic acid. In conclusion, the difference in the amount of the inhibitors generated by hepatocytes and tumor cells should contribute to the underlying mechanism in the difference in sensitivity of cells to gallic acid.
- 公益社団法人日本薬学会の論文
- 2001-03-01
著者
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Inoue Makoto
Department of Pediatrics, Shimane Medical University
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Inoue Makoto
名古屋市立大学 薬研究生薬学
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Inoue M
Lab. Of Medicinal Resources School Of Pharmacy Aichi Gakuin Univ.
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Ogihara Yukio
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
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Ogihara Yukio
Faculty Of Pharmacy Meijo Universitv
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Ogihara Yukio
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nogoya City University
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Ogihara Yukio
Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive
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Ogihara Yukio
Graduate School Of Pharmaceutical Sciences Nagoya City University
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Inoue M
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
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ISUZUGAWA Kazuto
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagoya City University
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Isuzugawa Kazuto
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nagoya City University
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Ogihara Y
Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive
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Inoue Makoto
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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