Metabolic Fate of Gallic Acid Orally Administered to Rats

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概要

• 論文の詳細を見る

• The metabolic behavior of orally administered gallic acid was investigated by HPLC and 4-O-methyl gallic acid was found to be the main metabolite in rat peripheral blood and urine. After oral administration of gallic acid, maximum concentration in portal vein and inferior vena cava occurred at 15 and 30 min, respectively. In portal vein, gallic acid was preferentially detected relative to 4-O-methyl gallic acid, whereas gallic acid and 4-O-mehyl gallic acid were equally detected in inferior vena cave. On the other hand, 4-O-methyl gallic acid but not gallic acid was found in liver. The contents of gallic acid and 4-O-methyl gallic acid in urine were nearly 100 times higher than those in blood. The ratio of 4-O-methyl gallic acid to total gallic acid metabolites in urine was from 0.55 to 0.76,indicating that a considerable amount of gallic acid was excreted without being metabolized. In this study we found that gallic acid administered orally existed in the blood for 6 h at most, and more than half was metabolized to 4-O-methyl gallic acid, followed by excretion into urine.

• 公益社団法人日本薬学会の論文
• 1999-03-15

著者

• Inoue Makoto

  Department of Pediatrics, Shimane Medical University

• Inoue M

  Lab. Of Medicinal Resources School Of Pharmacy Aichi Gakuin Univ.

• SAKAGUCHI Nahoko

  Department of Biochemistry, Nagoya University School of Medicine

• Kojima K

  Kyushu Univ. Fukuoka

• Ogihara Yukio

  Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University

• Ogihara Yukio

  Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nogoya City University

• Ogihara Yukio

  Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive

• Ogihara Yukio

  Graduate School Of Pharmaceutical Sciences Nagoya City University

• Inoue M

  Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University

• NOSE Mitsuhiko

  Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University

• NOSE Mitsuhiko

  Department of Pharmacognosy and Plant Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City Uni

• Kojima K

  Department Of Chemistry Faculty Of Science

• ISUZUGAWA Kazuto

  Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagoya City University

• ZONG Li

  The Drug Inspection Institute of Fujian Ports and Fujian Province

• KOJIMA Keisuke

  Department of Pharmacognosy, Faculty of Pharmaceutical Science, Nagoya City University

• TAKEDA Tadahiro

  Department of Pharmacognosy, Kyuritsu College of Pharmacy

• Isuzugawa Kazuto

  Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nagoya City University

• Kojima K

  Graduate School Of Pharmaceutical Sciences Nagoya City University

• Nose M

  Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University

• Takeda Tadahiro

  Department Of Pharmacognosy Kyuritsu College Of Pharmacy

• Sakaguchi N

  Nagoya Univ. School Of Medicine Nagoya Jpn

• Sakaguchi Nahoko

  Department Of Biochemistry Nagoya University School Of Medicine

• Inoue Makoto

  Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University

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