Effect of Karasurin-A on Nitric Oxide Production by Murine Macrophages and Mitogenic Response of Murine Splenocytes in Vitro

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概要

• 論文の詳細を見る

• We studied the effect of karasurin-A, a type-I ribosome-inactivating protein (RIP) isolated from fresh root tubers of Trichosanches kirilowii MAX. var. japonica KITAMURA, on the mitogenic response of murine splenocytes and nitric oxide (NO) production by murine peritoneal macrophages in vitro. Karasurin-A inhibited the lymphocyte proliferation by LPS, ConA and PHA and NO production by LPS at non-cytotoxic concentrations (10-1000 ng/ml for splenocytes and 10-100 ng/ml for macrophages, respectively). These data suggest that karasurin-A has immunosuppressive activity in vitro.

• 公益社団法人日本薬学会の論文
• 1997-04-15

著者

• 近藤 俊哉

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Kondo T

  Research Division The Green Cross Corporation

• Kojima K

  Kyushu Univ. Fukuoka

• Ogihara Yukio

  Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University

• Ogihara Yukio

  Faculty Of Pharmacy Meijo Universitv

• Ogihara Yukio

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Ogihara Yukio

  Graduate School Of Pharmaceutical Sciences Nagoya City University

• NOSE Mitsuhiko

  Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University

• MIZUKAMI Hajime

  Faculty of Pharmaceutical Sciences, Nagoya City University

• Kojima K

  Graduate School Of Pharmaceutical Sciences Nagoya City University

• TERAWAKI Kiyoshi

  Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University

• KONDO Toshiya

  Faculty of Pharmaceutical Sciences, Kitasato University

• Nose M

  Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University

• KOJIMA Keisuke

  Faculty of Pharmaceutical Sciences, Nagoya City University

• NOSE Mitsuhiko

  Faculty of Pharmaceutical Sciences, Nagoya City University

• TERAWAKI Kiyoshi

  Faculty of Pharmaceutical Sciences, Nagoya City University

• Mizukami Hajime

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Mizukami H

  Dep. Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City Univ.

• Terawaki Kiyoshi

  Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University

• Mizukami Hajime

  Faculty Of Pharmaceutical Science Nagoya City University

• Kojima Keisuke

  Faculty Of Pharmaceutical Sciences Nagoya City University

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