BLOCKADE BY ANTI-GLUCOCORTICOIDS, ACTINOMYCIN D AND CYCLOHEXIMIDE OF THE ANTI-INFLAMMATORY ACTION OF SOME KAMPOHOZAI (CHINESE TRADITIONAL MEDICINES) AGAINST SEROTONIN
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概要
- 論文の詳細を見る
Blockade by anti-glucocorticoids, progesterone and 17α-methyltestosterone, a messenger ribonucleic acid (m-RNA) synthesis inhibitor, actinomycin D, and a protein synthesis inhibitor, cycloheximide, of the anti-exudative action of five kinds of Kampohozai (Daisaikoto, Shosaikoto, Saikokeishito, Daiobotanpito and Tokakujokito) were studied to investigate mode of the anti-inflammatory action of those Kampohozai. The inflammatory lesion was provoked by injection of serotonin (0.3μg) in the Tyrode solution (5μl) in subplantar region of the hind paw of mice. The above anti-glucocorticoids and the m-RNA and protein synthesis inhibitors suppressed the anti-inflammatory effects of Daisaikoto and Shosaikoto dose-dependently. The action of Saikokeishito was suppressed weakly by treatment with progesterone of 17α-methyltestosterone, but not blocked by treatment with actinomycin D or cycloheximide. On the other hand, Daiobotanpito and Tokakujokito were not blocked by treatment with those four inhibitors. These results suggest that mechanism of anti-inflammatory action of Daisaikoto and Shosaikoto is similar to that of glucocorticoid but Daiobotanpito and Tokakujokito exert anti-inflammatory effects through some other mechanisms.
- 公益社団法人日本薬学会の論文
著者
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Ogihara Yukio
Faculty Of Pharmaceutical Sciences Nagoya City University
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AMAGAYA SAKAE
Faculty of Pharmaceutical Sciences, Nagoya City University
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Amagaya Sakae
Faculty Of Pharmaceutical Sciences Nagoya City University
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Amagaya Sakae
Faculty Of Pharmaceutical Sceinces Nagoya City University
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Higuchi Hirotaka
Faculty Of Pharmaceutical Sciences Nagoya City University
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