ANTI-INFLAMMATORY TESTING METHODS : COMPARATIVE EVALUATION OF MICE AND RATS
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概要
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The possibility of using mice in place of rats on the anti-inflammatory screening tests was investigated. The diversities of the responses between mice and rats on screening tests, that is, carrageenin, formalin-induced edema in the hind paw, adjuvant arthritis and cotton peller granuloma were observed with p.o. administration of prednisolone, 0.5 mg/kg and 5.0 mg/kg, and indomethacin, 0.5 mg/kg and 5.0 mg/kg. On the effects of these drugs on screening tests, a similar type of phenomena between rats and mice was found. Then the dose-response relationships of aspirin, flufenamic acid, phenylbutazone, cyproheptadine, prednisolone and indomethacin were examined in four kinds of screening tests mentioned above. Prednisolone, indomethacin, phenylbutazone and aspirin inhibited the carrageenin, formalin-induced edema, cotton pellet granuloma and adjuvant arthritis apparently, but flufenamic acid showed no inhibition on the carrageenin and formalininduced edema. Cyproheptadine inhibited the formalin and serotonin-induced edema. We have found that mice, instead of rats, can be used for the anti-inflammatory screening methods.
- 公益社団法人日本薬学会の論文
著者
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Ogihara Yukio
Faculty Of Pharmaceutical Sciences Nagoya City University
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Ogihara Yukio
Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive
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Ogihara Y
Nagoya City Univ. Nagoya Jpn
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Amagaya Sakae
Department Of Pharmacognosy Faculty Cf Pharmaceutical Sciences Nagoya City University
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SUGISHITA ETSUKO
Faculty of Pharmaceutical Sciences, Nagoya City University
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Sugishita Etsuko
Faculty Of Pharmaceutical Sciences Nagoya City University
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Sugishita Etsuko
Department Of Pharmacognosy Faculty Cf Pharmaceutical Sciences Nagoya City University
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Amagaya Sakae
Department of Kampo Pharmaceutical Sciences, Nihon Pharmaceutical University
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