LONG-TERM ADMINISTRATION OF "SHO-SAIKO-TO" INCREASES CYTOCHROME P-450 mRNA LEVEL IN MOUSE LIVER
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概要
- 論文の詳細を見る
Simplified differential display of mRNA was applied to isolate and identify genes transcriptionally regulated in mouse liver by sho-saiko-to administration. A cDNA fragment up-regulated by sho-saiko-to was isolated and characterized. cDNA sequencing and subsequent database analysis revealed that the fragment showed significant sequence similarity with mouse testosterone 16-alpha-hydroxylase (cytochrome P-450_<16α>) cDNA. The increased level of mRNA expression of cytochrome P-450_<16α> in association with sho-saiko-to administration suggests the molecular mechanism of the chemopreventive effect of sho-saiko-to. This result indicates the usefulness of the mRNA differential display technique to investigate the molecular mechanism of Kampo medicine.
- 公益社団法人日本薬学会の論文
- 1998-04-15
著者
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Inoue M
Lab. Of Medicinal Resources School Of Pharmacy Aichi Gakuin Univ.
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Kojima K
Kyushu Univ. Fukuoka
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Ogihara Yukio
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
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Ogihara Yukio
Faculty Of Pharmacy Meijo Universitv
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Ogihara Yukio
Faculty Of Pharmaceutical Sciences Nagoya City University
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Ogihara Yukio
Graduate School Of Pharmaceutical Sciences Nagoya City University
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Tazawa Takako
Faculty Of Pharmaceutical Sciences Nagoya City University
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Inoue M
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
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NOSE Mitsuhiko
Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University
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INOUE Makoto
Faculty of Pharmaceutical Sciences, Nagoya City University
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Kojima K
Department Of Chemistry Faculty Of Science
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MIZUKAMI Hajime
Faculty of Pharmaceutical Sciences, Nagoya City University
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Kojima K
Graduate School Of Pharmaceutical Sciences Nagoya City University
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Nose M
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
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KOJIMA Keisuke
Faculty of Pharmaceutical Sciences, Nagoya City University
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NOSE Mitsuhiko
Faculty of Pharmaceutical Sciences, Nagoya City University
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Mizukami Hajime
Faculty Of Pharmaceutical Sciences Nagoya City University
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Mizukami H
Dep. Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City Univ.
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Inoue Makoto
Faculty Of Agriculture Miyazaki University
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Mizukami Hajime
Faculty Of Pharmaceutical Sciences Nagasaki University
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Mizukami Hajime
Faculty Of Pharmaceutical Science Nagoya City University
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Kojima Keisuke
Faculty Of Pharmaceutical Sciences Nagoya City University
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