Anti-inflammatory and Cytotoxic Activities of Five Veronica Species
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概要
- 論文の詳細を見る
Biological activities of five Veronica species (Scrophulariaceae), V. cymbalaria, V. hederifolia, V.pectinata var. glandulosa, V. persica and V polita were studied for their anti-inflammatory and cytotoxic activities. Their methanol extracts showed both the inhibitory activity of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated macrophages and cytotoxic activity against KB epidermoid carcinoma and B16 melanoma. When the methanol extracts were fractionated between water and chloroform, water fractions significantly inhibited NO production without any cytotoxicity, while chloroform fractions showed cytotoxicity dose-dependently. When the radical scavenging activity was determined using 2,2-diphenyl-1-picryl-hydrazyl (DPPH), water fractions of the five Veronica species scavenged free radicals effectively, suggesting that the inhibitory effect of this species on NO production was due to their radical scavenging activity. On the other hand, chloroform fractions of Veronica species except for V. cymbalaria showed similar cytotoxic activity against KB and B16 melanoma cells.
- 社団法人日本薬学会の論文
- 2002-04-01
著者
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SARACOGLU Iclal
Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University
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Inoue Makoto
名古屋市立大学 薬研究生薬学
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Inoue M
Lab. Of Medicinal Resources School Of Pharmacy Aichi Gakuin Univ.
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Saracoglu Iclal
Department Of Pharmacognosy Faculty Of Pharmacy Hacettepe University
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Saracoglu Iclal
トルコ
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OGIHARA Yukio
Nihon Pharmaceutical University
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Ogihara Y
Nihon Pharmaceutical University
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Ogihara Yukio
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
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Ogihara Yukio
Faculty Of Pharmacy Meijo Universitv
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Ogihara Yukio
Graduate School Of Pharmaceutical Sciences Nagoya City University
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Inoue M
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
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HARPUT U.
Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University
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INOUE Makoto
Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University
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Harput Ummuhan
Department Of Pharmacognosy Faculty Of Pharmacy Hacettepe University:b Laboratory Of Pharmacognosy G
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Saracoglu I
Department Of Pharmacognosy Faculty Of Pharmacy Hacettepe University
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Inoue Makoto
Laboratory Of Metabolic Biochemistry Faculty Of Agriculture Tottori University
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Harput U.Sebnem
Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University
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Inoue Makoto
Laboratory of Medicinal Resources, School of Pharmacy, Aichi Gakuin University
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