Comparative Study of the High Molecular Mass Fraction and Low Molecular Mass Fraction of Sho-saiko-to in a Murine Immunologically Induced Liver Injury Model
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概要
- 論文の詳細を見る
We compared the pharmacological actions of the high and low molecular mass fractions of Sho-saiko-to using a murine immunologically induced liver injury model to estimate the roles of these fractions in the expression of the pharmacological action. In a Bacillus Calmette-Guerin(BCG)/lipopolysaccharide(LPS)-induced liver injury model, Sho-saiko-to and both of its fractions significantly reduced the increases in the aminotranseferase levels in serum. They also reduced the increase in the nitric oxide(NOx)level in serum. On the other hand, Sho-saiko-to and its high molecular mass fraction suppressed the increase in plasma NOx level in an LPS-induced endotoxin shock model but its low molecular mass fraction did not. These results suggest the possibility that both fractions act hepatoprotectively in a different manner. We believe that these results can help to elucidate the mechanism of action of ingredients in Sho-saiko-to.
- 公益社団法人日本薬学会の論文
- 2002-01-01
著者
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OGIHARA Yukio
Nihon Pharmaceutical University
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Ogihara Y
Nihon Pharmaceutical University
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Ogihara Yukio
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
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Ogihara Yukio
Faculty Of Pharmacy Meijo Universitv
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NOSE Mitsuhiko
Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University
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TERAWAKI Kiyoshi
Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University
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IWAHASHI Naomi
Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University
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OGURI Kanayo
Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University
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Iwahashi Naomi
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
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Nose M
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
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Nose Mitsuhiko
Laboratory Of Pharmacognosy Meijo University Faculty Of Pharmacy
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Oguri K
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
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Terawaki Kiyoshi
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
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