New Lignan Glycosides from Chinese Medicinal Plant, Sinopodophillum emodi

概要

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Two new podophillotoxin glucosidcs, L-picropodophillotpxin 7'-0-(β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside) (2) and L-picropodophillotpxin 7'-0-β-D-glucopyranoside (3), were isolated from Chinese medicinal plant, Sinopodophillum emodi, together with 4 known compounds, podophillotoxin (1), podorhizol 4'-O-β-D-glucopyranoside (4), deoxypodophillotoxin (5), and dehydropodophillotoxin (6). The structures of 2 and 3 were finally determined by the extensive decouping and nuclear Overhauser effect (NOE) experiments in NMR spectra and circular dichroism (CD) spectra. Compound 2 is the second example of podophillotoxin diglucoside, and both the first one and 2 were isolated from S. emodi. X-ray crystal structure analysis of 1, 5, and 6 was carried out. Compounds 1 and 5 showed the different conformations from those reported.
公益社団法人日本薬学会の論文
2003-03-01