36 モンゴル産薬用植物Ferula ferulioidesに含まれる新規セスキテルペン誘導体の構造(口頭発表の部)

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Ferula ferulioides (STEUD.) KOROVIN (Umbelliferae) grows in Bulgan Somon of Hovd City, Mongolia, and has been used as a traditional medicine for the treatment of spasm. The present investigation deals with the isolation and the structural elucidation of twenty four novel sesquiterpenoid derivatives (5-28), together with four known compounds (1-4) from F. ferulioides. The dried root powder was extracted with methanol, and removal of the solvent gave waxy solid which was successively extracted with ethyl acetate and water. From the ethyl acetate extract, twenty four novel compounds (5-28) were isolated, together with four known compounds, myristicin (1), guaiol (2), nerolidol (3) and dshamirone (4). Myristicin is a phenylpropanoid derivative; nerolidol and guaiol are sesquiterpenes. Compounds 5-28 were identified as farnesyl-acetophenone type (5-8), fanesyl-benzofranone type (9), prenyl-benzoylfuranone type (10-12), 3-prenyl-furocoumarin type (13-16), 2-prenyl-furocoumarin type (17-25), and 2-prenyl-furochromone type (26-28) new sesquiterpenoid derivatives by comprehensive spectral analysis. A series of NOESY experiments was carried out with 10-28 to identify the relative stereochemistry. The biosynthetic pathway leading to these compounds is proposed based on their structures. Compounds 4-28 were divided into groups A-F by their biosynthetic routes. In addition, the presence of the hypothetical precursors classified into three groups (I-III) was suggested.
天然有機化合物討論会の論文
1999-09-01

36 モンゴル産薬用植物Ferula ferulioidesに含まれる新規セスキテルペン誘導体の構造(口頭発表の部)

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