94(P31) 油糧種子に含有される抗酸化物質の研究 : ベニバナ油粕及び綿実油粕に含有される抗酸化物質の探索(ポスター発表の部)
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Antioxidants were widely used for food protection, and some of them are also for the defense of biological molecules against oxidative damage. However, synthetic antioxidants are suspected to be carcinogenic and toxic, and use of the natural antioxidants is desired. In the course of our investigation on natural antioxidants, we focused on the oil cake. Oil plants should have antioxidants in their seeds to prevent their oil from oxidative damage, and the antioxidants from oil cakes would develop their utilities and should improve ecological problems in oil industry. Here we report isolation and identification of antioxidants (1-11) from safflower and cotton oil cake. The dried safflower oil cake was extracted with hot MeOH. After the partition of the extract, the EtOAc-soluble fraction was separated by repeated SiO_2 column chromatography and HPLC to yield the seven serotonin derivatives, 1 (322mg), 2 (371mg), 3 (12.4mg), 4 (18.1mg), 5 (4.0mg) 6 (396mg) and 7 (184mg), respectively. The dried cotton oil cake was extracted with MeOH. The EtOAC-soluble was separated by the similar method as isolation of 1-7 to yield compounds 8 (5.0mg), 9 (5.7mg), 10 (6,3mg) and 11 (7.0mg). Structures of 1-11 was established mainly by detailed analysis of the various NMR spectra. Their antioxidative activity of 1-11 were determined by the ferric thiocyanate method and the DPPH radical scavenging activity assay. In these tests, compounds 1-5, 9, 10 and 11 were stronger antioxidative activity than the commonly used natural antioxidant (α-tocopherol) and comparable to synthetic antioxidant (BHA). Thus these compounds were supposed to play an important role in prevention of oil oxidation in the plants and could become food additive.
- 天然有機化合物討論会の論文
- 1997-07-20
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