ネジキLyonia ovalifolia DRUDE var. elliptica HAND.-MAZZ.の成分研究(第18報)Diterpenoid, Lyoniol-Dの構造およびLyoniol-A(Lyoniatoxin)とGrayanotoxin-Iの関連について
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Along with previously reported lyoniol-A and -B, the toxic principles of Lyonia ovalifolia var. elliptica, a new toxic diterpene named lyoniol-D was isolated and the structure (I) has been proposed on the basis of spectral data, chemical reactions, and correlation with lyoniol-A. Lyoniol-A (II) was chemically correlated with grayanotoxin-I (XI) through the conversion of both to a common substance, 3,6-dioxo-5,10,16-trihydroxygrayanane (XX=XXII). Therefore, the structures of lyoniol-A and -D have been unambiguosly established as II and I, respectively, since the structure of grayanotoxin-I was already determined as XI by the X-ray structural study. Several hitherto undescribed derivatives of were also prepared in the course of the attempted correlation of above described lyoniols.
- 社団法人日本薬学会の論文
- 1974-12-25
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