The Oxidized Products of 8-Methoxypsoralen (8-MOP) with H_2O_2-NaOCl
スポンサーリンク
概要
- 論文の詳細を見る
In order to obtain adducts of 8-methoxypsoralen (8-MOP, 1) and singlet oxygen (^1O_2), the oxidation of 1 with chemically generated singlet oxygen in H_2O_2-NaOCl was undertaken. Bioassay-directed fractionation of the crude oxidized products has led to the isolation and characterization of a novel derivative of 1,2,3-dihydro-2,9-dimethoxy-3-hydroxy-7H-furo[3,2-g][1]benzopyran-7-one (2) as a substance inhibiting chemotactic activity of polymorphonuclear neutrophils toward anaphylatoxin C5_a des Arg. The structure of 2 was determined from the spectroscopic data and by correlation with its acetate (2a). Furthermore, the oxidation of 1 in H_2O_2-NaOCl afforded 5-chloro-9-methoxy-7H-furo[3,2-g][1]benzopyran-7-one (3) and 6-formyl-7-hydroxy-8-methoxy-2H-1-benzopyran-2-one (4) along wiht 1,but they exhibited no such activity.
- 社団法人日本薬学会の論文
- 1991-10-25
著者
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植田 泰誠
Faculty of Pharmaceutical Sciences, Nagoya City University
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村上 啓寿
Faculty of Pharmaceutical Sciences, Nagoya City University
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永井 慎一
Faculty of Pharmaceutical Sciences, Nagoya City University
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榊原 仁作
Faculty of Pharmaceutical Sciences, Nagoya City University
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榊原 仁作
名市大院薬
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榊原 仁作
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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永井 慎一
名市大薬
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森本 隆司
Faculty of Pharmaceutical Sciences, Nagoya City University
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松尾 恵子
Faculty of Pharmaceutical Sciences, Nagoya City University
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水野 信行
Department of Dermatology, Nagoya City University Medical School
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江崎 健司
Department of Dermatology, Nagoya City University Medical School
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榊原 仁作
名古屋市大 大学院 薬
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村上 啓寿
Faculty Of Pharmaceutical Sciences Osaka University
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森本 隆司
Faculty Of Pharmaceutical Sciences Nagoya City University
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植田 泰誠
Faculty Of Pharmaceutical Sciences Nagoya City University
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榊原 仁作
Faculty Of Pharmaceutical Sciences Nagoya City University
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村上 啓寿
Faculty Of Pharmaceutical Sciences Nagoya City University:(present Address)kyoto Pharmaceutical Univ
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松尾 恵子
Faculty Of Pharmaceutical Sciences Nagoya City University
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水野 信行
Department Of Dermatology Nagoya City University Medical School
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江崎 健司
Department Of Dermatology Nagoya City University Medical School
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